RDK Rare Disease Knowledge®

6 200 rare diseases in your coat pocket

Your assistant from the first symptoms to
referral to the appropriate expert center.

Co-developed with

RDK Phone and Laptop mockup

They support us

Alliances Maladies Rares

All your research at your fingertips

Search for rare diseases

Based on a combination of signs or symptoms observed and entered into our Assistant Tool.

Access knowledge

Includes a complete fact sheet based on Orphanet data and recent publications.

Referral to expert centres

Find the expert centres likely to diagnose and manage patients.

Who is this application for?

The battle begins with diagnosis



Alliance Maladies Rares President

“It takes an average of 4 years to be referred to an expert center, and depending on the pathology, this diagnostic errancy can last 5, 10 or even a lifetime. For these progressive and often disabling diseases, a delay in diagnosis has disastrous consequences for the health, morale, education, social and family life, budget and treatment of the people concerned. And, sadly, this delay sometimes leads to the early death of children and adults affected by a rare disease [....]. The RDK app provides an effective response and a long-awaited technological solution for the rare disease community, including patients.”



Orphanet Director

“By helping doctors to guide and manage patients who may suffer from rare diseases, RDK is an application of high social value that optimizes the knowledge developed by Orphanet over the last 25 years thanks to public support.”


“A very fluid, attractive and easy to use application. The symptomatic approach in the main menu is very interesting for practitioners [...] The disease data sheets are well constructed.”

Simon M.

Medical intern

“RDK meets a key demand

Dr. Charles W.

General Medicine Intern

“Very useful for specialists [...] essential for supporting diagnosis and therefore better targeting of genetic testing.”

Dr. Aymeric L.


Rare diseases in a few key figures

6 354

Rare diseases


Are genetic in origin, affecting patients from childhood

300 million

Patients in the world

2 to 7 years

Of misdiagnosis

RDK, an essential ally for doctors in the fight against rare diseases. Watch our video:

Access all centralised knowledge

Orphanet Data

Updated, supplied and enriched by Orphanet with your feedback

Expert centers*

Sorted by relevance or via an interactive map, with departmental contacts.

*Labelling by the Ministry of Health (France)

Signs and symptoms

Sorted by frequency. Description, synonyms and anatomical classification.

Clinical trials


List of clinical trials currently recruiting, description and contact details.


Case studies and scientific reviews on rare diseases.


Documents, reccommedations, and emergency guidelines for the attending physician.

Clinical description

Written and updated by Orphanet.


List of genes involved with their symbols and synonyms.

Download RDK for free

A unique partnership

Co-developed by Orphanet and Tekkare

A public-private partnership based on Orphanet's scientific expertise, Tekkare®'s technology, and the social commitment of as we know®.


Scientific partnership


Created by Inserm, to pool knowledge on rare diseases in order to improve the diagnosis, care, and treatment of patients.


Technical partnership


French company developing digital ecosystems to make the most of healthcare data, and share medical and scientific knowledge.

Our sponsors

The sponsors help to fund the development of the application. All content, design and features presented in the application are produced entirely independently.

Show your commitment to the fight for diagnosis of rare diseases by joining us.

I want to become a sponsor

Do you have questions?

Go further with RDK

Here are some articles on frequently asked questions, use cases, and tutorials that may be of interest to you

Health professionals


Become a contributor

Would you like to help us improve the RDK, add a symptom or suggest a new feature?

Read more →

Health professionals


My first steps on RDK

A short video introducing the Assistant tool and all the navigation secrets of RDK.

Read more →

View more articles →

We are being talked about

Our media presence

Talents E-Santé

Talents e-santé 2023 award winners

Outpatient Digital Innovation Award for our RDK Rare Disease Knowledge application

View article ↗

Maladies Rares Info Services

Maladies Rares Info Services

Listed as a resource for healthcare professionals in France.

View article ↗


Newsletter Orphanet

Orphanews France is a newsletter about rare diseases and orphan drugs.

View article ↗


RDK is a connected medical device (class I)


as we know®, the manufacturer of RDK, has registered RDK with the ANSM as a class I connected medical device, in accordance with article R5211-65 of the French Public Health Code (Acknowledgement of receipt from the ANSM dated 19 January 2023).

CE Marking

as we know®, the manufacturer of RDK, has declared the conformity of RDK as a «sofwtare as medical device» (class I) in order to obtain CE marking.